• 姓名: 王道文
  • 职称: 研究员
  • 学位: 博士
  • 河南农业大学
  • 农学院
作物生物技术系
       王道文 1965年生,博士,研究员,国家***科学基金获得者、***专家、新世纪***万人才工程国家级人选,现任河南农业大学学术副校长和农学院院长,主要研究植物分子生物学和小麦基因组学与遗传改良。1985年于河南农业大学获得学士学位,1993年在英国University of East Anglia/John Innes Center获得博士学位,1993-1997在John Innes Center开展博士后研究。1991年以来,以第一或通讯作者身份在Nature、Science、Nature Genetics、Science Advances、PNAS、Plant Cell、New Phytologist、Plant Biotechnology Journal、Plant Journal、Journal of Integrative Plant Biology、Theoretical and Applied Genetics等刊物发表论文70余篇,获中华农业科技奖一等奖1项(第二完成人)。
       王道文团队作为主要力量之一完成小麦A基因组测序与精细图谱绘制,研究论文分别于2013和2018年发表于Nature,领衔完成威宁黑麦基因组精细物理图谱构建,研究结果于2021年发表于Nature Genetics;建立了利用系列突变体解析并改良小麦品质的研究体系,相关论文发表于Molecular Plant等刊物;通过分子和常规育种技术结合,培育出优质强筋小麦新品种科兴3302、营养强化功能小麦新品种豫州黑麦1号和2号、耐盐丰产小麦新品种豫州810和科兴789。“十一五”和“十二五”期间,作为首席科学家主持并完成了两个国家重点基础研究发展规划项目(973项目)的研究,现主持“十三五”国家重点研发计划项目“主要农作物品质性状形成的分子基础”的研究。

研究方向:1)小麦重要农艺性状(品质、抗病、耐逆等)形成、变异与改良的分子基础;2)麦类植物基因组比较研究;3)小麦种质资源创新及分子育种。
讲授课程:作物科学研究进展(博士研究生课程)。
电子邮箱:dwwang@henau.edu. cn. daowenwanghau@163.com.
ORCID  https://orcid.org/0000-0002-6230-8735.

代表性研究论文(*标注通讯或共同通讯作者)
1. Qi G, Chen H, Wang D, Zheng H, Tang X, Guo Z, Cheng J, Chen J, Wang Y, Bai MY, Liu F, Wang D*, Fu ZQ*. The BZR1-EDS1 module regulates plant growth-defense coordination. Molecular Plant. 2021; Epub ahead of print. PMID: 34416351.
2. Li G, Wang L, Yang J*, He H, Jin H, Li X, Ren T, Ren Z, Li F, Han X, Zhao X, Dong L, Li Y, Song Z, Yan Z, Zheng N, Shi C, Wang Z, Yang S, Xiong Z, Zhang M, Sun G, Zheng X, Gou M, Ji C, Du J, Zheng H, Doležel J, Deng XW, Stein N, Yang Q*, Zhang K*, Wang D*. A high-quality genome assembly highlights rye genomic characteristics and agronomically important genes. Nature Genetics. 2021; 53: 574-584.
3. Zhai H, Jiang C, Zhao Y, Yang S, Li Y, Yan K, Wu S, Luo B, Du Y, Jin H, Liu X, Zhang Y, Lu F, Reynolds M, Ou X, Qiao W, Jiang Z, Peng T, Gao D, Hu W, Wang J, Gao H, Yin G, Zhang K*, Li G*, Wang D*. Wheat heat tolerance is impaired by heightened deletions in the distal end of 4AL chromosomal arm. Plant Biotechnology Journal. 2021; 19: 1038-1051.
4. Xia T, Yang Y, Zheng H, Han X, Jin H, Xiong Z, Qian W, Xia L, Ji X, Li G*, Wang D*, Zhang K*. Efficient expression and function of a receptor-like kinase in wheat powdery mildew defence require an intron-located MYB binding site. Plant Biotechnology Journal. 2021; 19: 897-909.
5. Wang D*, Li F, Cao S, Zhang K*. Genomic and functional genomics analyses of gluten proteins and prospect for simultaneous improvement of end-use and health-related traits in wheat. Theoretical and Applied Genetics. 2020; 133: 1521-1539.
6. Jin H, Du Z, Zhang Y, Antal J, Xia Z, Wang Y, Gao Y, Zhao X, Han X, Cheng Y, Shen Q, Zhang K, Elder RE, Benko Z, Fenyvuesvolgyi C, Li G, Rebello D, Li J, Bao S, Zhao RY*, Wang D*. A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1. Science Advances. 2020; 6: eaba3418.
7. Ji X*, Yang B, Wang D*. Achieving plant genome editing while bypassing tissue culture. Trends in Plant Science. 2020; 25: 427-429.
8. Zheng H, Dong L, Han X, Jin H, Yin C, Han Y, Li B, Qin H, Zhang J, Shen Q, Zhang K*, Wang D*. The TuMYB46L-TuACO3 module regulates ethylene biosynthesis in einkorn wheat defense to powdery mildew. New Phytologist. 2020; 225: 2526-2541.
9. Cao X, Dong Z, Tian D, Dong L, Qian W, Liu J, Liu X, Qin H, Zhai W, Gao C, Zhang K*, Wang D*. Development and characterization of marker-free and transgene insertion site-defined transgenic wheat with improved grain storability and fatty acid content. Plant Biotechnology Journal. 2020;18: 129-140.
10. Zhang K*, Wang J, Qin H, Wei Z, Hang L, Zhang P, Reynolds M, Wang D*. Assessment of the individual and combined effects of Rht8 and Ppd-D1a on plant height, time to heading and yield traits in common wheat. The Crop Journal. 2019; 7: 845-856.
11. Ling HQ*, Ma B, Shi X, Liu H, Dong L, Sun H, Cao Y, Gao Q, Zheng S, Li Y, Yu Y, Du H, Qi M, Li Y, Lu H, Yu H, Cui Y, Wang N, Chen C, Wu H, Zhao Y, Zhang J, Li Y, Zhou W, Zhang B, Hu W, van Eijk MJT, Tang J, Witsenboer HMA, Zhao S, Li Z, Zhang A*, Wang D*, Liang C*. Genome sequence of the progenitor of wheat A subgenome Triticum urartu. Nature. 2018; 557: 424-428.
12. Qi G, Chen J, Chang M, Chen H, Hall K, Korin J, Liu F, Wang D*, Fu ZQ*. Pandemonium breaks out: disruption of salicylic acid-mediated defense by plant pathogens. Molecular Plant. 2018; 11: 1427-1439.
13. Li D, Jin H, Zhang K, Wang Z, Wang F, Zhao Y, Huo N, Liu X, Gu YQ, Wang D*, Dong L*. Analysis of the Gli-D2 locus identifies a genetic target for simultaneously improving the breadmaking and health-related traits of common wheat. Plant Journal. 2018; 95: 414-426.
14. Xiao J, Dong L, Jin H, Zhang J, Zhang K, Liu N, Han X, Zheng H, Zheng W*, Wang D*. Reactions of Triticum urartu accessions to two races of the wheat yellow rust pathogen. The Crop Journal. 2018; 6: 509-515.
15. Zhang Y,  Li D,  Zhang D,  Zhao X,  Cao X,  Dong L,  Liu J,  Chen K,  Zhang H,  Gao C*,  Wang D*. Analysis of the functions of TaGW2 homoeologs in wheat grain weight and protein content traits. Plant Journal 2018; 94: 857-866.
16. Wang D*, Zhang K, Dong L, Dong Z, Li Y, Hussain A, Zhai H. Molecular genetic and genomic analysis of wheat milling and end-use traits in China: Progress and perspectives. The Crop Journal 2018; 6: 68-81.
17. Lou H, Dong L, Zhang K, Wang DW, Zhao M, Li Y, Rong C, Qin H, Zhang A, Dong Z, Wang D*. High-throughput mining of E-genome-specific SNPs for characterizing Thinopyrum elongatum introgressions in common wheat. Molecular Ecology Resources 2017; 17: 1318-1329.
18. Wang Z, Li Y, Yang Y, Liu X, Qin H, Dong Z, Zheng S, Zhang K, Wang D*. New insight into the function of wheat glutenin proteins as investigated with two series of genetic mutants. Scientific Reports 2017; 7: 3428.
19. Dong ZY, Yang Y, Zhang KP, Li YW, Wang JJ, Wang ZJ, Liu XJ, Qin HJ, Wang D*. Development of a new set of molecular markers for examining Glu-A1 variants in common wheat and ancestral species. PLoS One 2017; 12: e0180766.
20. Wang DW, Li D, Wang J, Zhao Y, Wang Z, Yue G, Liu X, Qin H, Zhang K, Dong L, Wang D*. Genome-wide analysis of complex wheat gliadins, the dominant carriers of celiac disease epitopes. Scientific Reports 2017; 7: 44609.
21. Zong Y, Xi X, Li S, Chen W, Zhang B, Liu D, Liu B*, Wang D*, Zhang HG*. Allelic variation and transcriptional isoforms of wheat TaMYC1 gene regulating anthocyanin synthesis in pericarp. Frontiers in Plant Science 2017; 8: 1645.
22. Zhang J, Li B, Yang Y, Mu P, Qian W, Dong L, Zhang K, Liu X, Qin H, Ling H, Wang D*. A novel allele of L-galactono-1,4-lactone dehydrogenase is associated with enhanced drought tolerance through affecting stomatal aperture in common wheat. Scientific Reports 2016; 6: 30177.
23. Dong L, Huo N, Wang Y, Deal K, Wang D, Hu T, Dvorak J, Anderson OD, Luo MC, Gu YQ*. Rapid evolutionary dynamics in a 2.8-Mb chromosomal region containing multiple prolamin and resistance gene families in Aegilops tauschii. Plant Journal 2016; 87: 495-506.
24. Zhang J, Zheng H, Li Y, Li H, Liu X, Qin H, Dong L, Wang D*. Coexpression network analysis of the genes regulated by two types of resistance responses to powdery mildew in wheat. Scientific Reports 2016; 6: 23805.
25. Li Y, An X, Yang R, Guo X, Yue G, Fan R, Li B, Li Z, Zhang K, Dong Z, Zhang L, Wang J, Jia X, Ling HQ, Zhang A*, Zhang X*, Wang D*. Dissecting and enhancing the contributions of high-molecular-weight glutenin subunits to dough functionality and bread quality. Molecular Plant 2015; 8: 332-334.
26. Dong L, Liu H, Zhang J, Yang S, Kong G, Chu JSC, Chen N*, Wang D*. Single-molecule real-time transcript sequencing facilitates common wheat genome annotation and grain transcriptome research. BMC Genomics 2015; 16: 1039.
27. Dong Z*, Feng B, Liang H, Rong C, Zhang K, Cao X, Qin H, Liu X, Wang T, Wang D*. Grain-specific reduction in lipoxygenase activity improves flour color quality and seed longevity in common wheat. Molecular Breeding 2015; 35: 150.
28. Yang Y, Li S, Zhang K, Dong Z, Li Y, An X, Chen J, Chen Q, Jiao Z, Liu X, Qin H, Wang D*. Efficient isolation of ion beam-induced mutants for homoeologous loci in common wheat and comparison of the contributions of Glu-1 loci to gluten functionality. Theoretical and Applied Genetics 2014; 127: 359-372.
29. Cao P, Ren Y, Zhang K, Teng W, Zhao X, Dong Z, Liu X, Qin H, Li Z, Wang D*, Tong Y*. Further genetic analysis of a major quantitative trait locus controlling root length and related traits in common wheat. Molecular Breeding 2014; 33: 975-985.
30. Dong L, Wang F, Liu T, Dong Z, Li A, Jing R, Mao L, Li Y, Liu X, Zhang K*, Wang D*. Natural variation of TaGASR7-A1 affects grain length in common wheat under multiple cultivation conditions. Molecular Breeding 2014; 34: 937-947.
31. Ling HQ*, Zhao S, Liu D, Wang J, Sun H, Zhang C, Fan H, Li D, Dong L, Tao Y, Gao C, Wu H, Li Y, Cui Y, Guo X, Zheng S, Wang B, Yu K, Liang Q, Yang W, Lou X, Chen J, Feng M, Jian J, Zhang X, Luo G, Jiang Y, Liu J, Wang Z, Sha Y, Zhang B, Wu H, Tang D, Shen Q, Xue P, Zou S, Wang X, Liu X, Wang F, Yang Y, An X, Dong Z, Zhang K, Zhang X, Luo MC, Dvorak J, Tong Y, Wang J, Yang H, Li Z*, Wang D*, Zhang A*, Wang J*. Draft genome of the wheat A-genome progenitor Triticum urartu. Nature 2013; 496: 87-90.
32. Zhang K, Wang J, Zhang L, Rong C, Zhao F, Peng T, Li H, Cheng D, Liu X, Qin H, Zhang A, Tong Y, Wang D*. Association analysis of genomic loci important for grain weight control in elite common wheat varieties cultivated with variable water and fertiliser supply. PLoS One 2013; 8: e57853.
33. Dong Z, Yang Y, Li Y, Zhang K, Lou H, An X, Dong L, Gu YQ, Anderson OD, Liu X, Qin H, Wang D*. Haplotype variation of Glu-D1 locus and the origin of Glu-D1d allele conferring superior end-use qualities in common wheat. PLoS One 2013; 8: e74859.
34. Feng B, Dong Z, Xu Z, Wang D*, Wang T*. Molecular characterization of a novel type of lipoxygenase (LOX) gene from common wheat (Triticum aestivum L.). Molecular Breeding 2012; 30: 113-124.
35. Wang F, Zhao S, Han Y, Shao Y, Dong Z, Gao Y, Zhang K, Liu X, Li D, Chang J, Wang D. Efficient and fine mapping of RMES1 conferring resistance to sorghum aphid Melanaphis sacchari. Molecular Breeding. 2013; 31: 777-784.
36. Wu C, Feng J, Wang R, Liu H, Yang H, Rodriguez PL, Qin H, Liu X, Wang D*. HRS1 acts as a negative regulator of abscisic acid signaling to promote timely germination of Arabidopsis seeds. PLoS One 2012; 7: e35764.
37. Wang GF, Wei X, Fan R, Zhou H, Wang X, Yu C, Dong L, Dong Z, Wang X, Kang Z, Ling H, Shen QH, Wang D*, Zhang X*. Molecular analysis of common wheat genes encoding three types of cytosolic heat shock protein 90 (Hsp90): functional involvement of cytosolic Hsp90s in the control of wheat seedling growth and disease resistance. New Phytologist 2011; 191: 418-431.
38. Yu C, Li Y, Li B, Liu X, Hao L, Chen J, Qian W, Li S, Wang G, Bai S, Ye H, Qin H, Shen Q, Chen L, Zhang A, Wang D*. Molecular analysis of phosphomannomutase (PMM) genes reveals a unique PMM duplication event in diverse Triticeae species and the main PMM isozymes in bread wheat tissues. BMC Plant Biology 2010; 10: 214.
39. Dong L, Zhang X, Liu D, Fan H, Sun J, Zhang Z, Qin H, Li B, Hao S, Li Z, Wang D*, Zhang A*, Ling HQ*. New insights into the organization, recombination, expression and functional mechanism of low molecular weight glutenin subunit genes in bread wheat. PLoS one 2010; 5: e13548.
40. Feng B, Dong Z, Xu Z, An X, Qin H, Wu N, Wang D*, Wang T*. Molecular analysis of lipoxygenase (LOX) genes in common wheat and phylogenetic investigation of LOX proteins from model and crop plants. Journal of Cereal Science 2010; 52: 387-394.
41. An XL, Yu CM, Wang D*. Assessment of plant gene functions using viral vectors. In: Wang A, ed. Principles and Practice of Advanced Technology in Plant Virology. Research Signpost 2010; pp 311-330.
42. Yang H, Liu H, Li G, Feng J, Qin H, Liu X, Xue H, Wang D*. Reduction of root flavonoid level and its potential involvement in lateral root emergence in Arabidopsis thaliana grown under low phosphate supply. Functional Plant Biology 2009; 36: 1-10.
43. Ding Z, Li S, An X, Liu X, Qin H, Wang D*. Transgenic expression of MYB15 confers enhanced sensitivity to abscisic acid and improved drought tolerance in Arabidopsis thaliana. Journal of Genetics and Genomics 2009; 36: 17-29.
44. Liu H, Yang H, Wu C, Feng J, Liu X, Qin H, Wang D*. Overexpressing HRS1 confers hypersensitivity to low phosphate-elicited inhibition of primary root growth in Arabidopsis thaliana. Journal of Integrative Plant Biology 2009; 51: 382-392.
45. Qin C, Qian W, Wang W, Wu Y, Yu C, Jiang X, Wang D*, Wu P*. GDP-mannose pyrophosphorylase is a genetic determinant of ammonium sensitivity in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of USA 2008; 105: 18308-18313.
46. Xia Z, Wang Y, Du Z, Li J, Zhao R, Wang D*. A potential nuclear envelope-targeting domain and an arginine-rich RNA binding element identified in the putative movement protein of the GAV strain of Barley yellow dwarf virus. Functional Plant Biology 2008; 35: 40-50.
47. Li Z, Zhang X*, Zhang H, Cao S, Wang D*, Hao S, Li L, Li H, Wang X. Isolation and characterization of a novel variant of HMW glutenin subunit gene from the St genome of Pseudoroegneria stipifolia. Journal of Cereal Science 2008; 47: 429-437.
48. Qian W, Yu C, Qian H, Liu X, Zhang A, Johansen IE, Wang D*. Molecular and functional analysis of phosphomannomutase (PMM) from higher plants and genetic evidence for the involvement of PMM in ascorbic acid biosynthesis in Arabidopsis and Nicotiana benthamiana. Plant Journal 2007; 49: 399-413.
49. Zhou H, Li S, Deng Z, Wang X, Chen T, Zhang J, Chen S, Ling H, Zhang A, Wang D*, Zhang X*. Molecular analysis of three new receptor-like kinase genes from hexaploid wheat and evidence for their participation in wheat hypersensitive response to stripe rust fungus infection. Plant Journal 2007; 52: 420-434.
50. Liu X, Qian W, Liu X, Qin H, Wang D*. Molecular and functional analysis of hypoxanthine-guanine phosphoribosyltransferase from Arabidopsis thaliana. New Phytologist 2007; 175: 448-461.
51. Mo P, Zhu Y, Liu X, Zhang A, Yang C, Wang D*. Identification of two phosphatidylinositol/phosphatidylcholine transfer protein genes that are predominately transcribed in the flowers of Arabidopsis thaliana. Journal of Plant Physiology 2007; 164: 478-486.
52. Niu Y, Chen K, Wang J, Liu X, Qin H, Zhang A, Wang D*. Molecular and functional characterization of sphingosine-1-phosphate lyase homolog from higher plants. Journal of Integrative Plant Biology 2007; 49: 323-335.
53. Chen K, Xu M, Li G, Liang H, Xia Z, Liu X, Zhang J, Zhang A, Wang D*. Identification of AtENT3 as the main transporter for uridine uptake in Arabidopsis roots. Cell Research 2006; 16: 377-388.
54. Liu X, Liu X, Zhang J, Xia Z, Liu X, Qin H, Wang D*. Molecular and functional characterization of sulfiredoxin homologs from higher plants. Cell Research 2006; 16: 287-296.
55. Zhang J, Zhu H, Liang H, Liu K, Zhang A, Ling HQ, Wang D*. Further analysis of the function of AtBHLH29 in regulating the iron uptake process in Arabidopsis thaliana. Journal of Integrative Plant Biology 2006; 48: 75-84.
56. Sun X, Wang D*, Hu S, Liu X, Zhang A, Qian W, Hao S. Characterization of the HMW glutenin subunits from Aegilops searsii and identification of a novel variant HMW glutenin subunit. Theoretical and Applied Genetics 2006; 113: 631-641.
57. Zhu H, Qian W, Lu X, Li D, Liu X, Liu K, Wang D*. Expression patterns of purple acid phosphatase genes in Arabidopsis organs and functional analysis of AtPAP23 predominantly transcribed in flower. Plant Molecular Biology 2005; 59: 581-594.
58. Li W, Wan Y, Liu Z, Liu K, Liu X, Li B, Li Z, Zhang X, Dong Y, Wang D*. Molecular characterization of HMW glutenin subunit allele 1Bx14: further insights in to the evolution of Glu-B1-1 alleles in wheat and related species. Theoretical and Applied Genetics 2004; 109: 1093-1104.
59. Bai J, Liu K, Jia X, Wang D*. An analysis of homoeologous microsatellites from Triticum urartu and Triticum monococcum. Plant Science 2004; 166: 341-347.
60. Li G, Liu K, Baldwin S, Wang D*. Equilibrative nucleoside transporters of Arabidopsis thaliana: cDNA cloning, expression pattern and analysis of transport activities. Journal of Biological Chemistry 2003; 278: 35732-35742.
61. Liu Z, Yan Z, Wan Y, Liu K, Zheng Y, Wang D*. Analysis of HMW glutenin subunits and their coding sequences in two diploid Aegilops species. Theoretical and Applied Genetics 2003; 106: 1368-1378.
62. Li D, Zhu H, Liu K, Leggewie G, Udvardi M, Wang D*. Purple acid phosphatases of Arabidopsis thaliana: comparative analysis and differential regulation by phosphate deprivation. Journal of Biological Chemistry 2002; 277: 27772-27781.
63. Li J, Wang D*. Cloning and in vitro expression of the cDNA encoding a putative nucleoside transporter from Arabidopsis thaliana. Plant Science 2000; 157: 23-32.
64. Wan Y, Liu KF, Wang D*, Shewry PR. High molecular weight subunits in the Cylindropyrum and Vertebrata section of the Aegilops genus and identification of subunits related to those encoded by the Dx alleles of common wheat. Theoretical and Applied Genetics 2000; 101: 879-884.
65. Wang D, Macfarlane SA, Maule AJ*. Viral determinants of pea early browning virus seed transmission in pea. Virology 1997; 234: 112-117.
66. Wang D, Maule AJ*. Contrasting patterns in the spread of two seed�\borne viruses in pea embryos. Plant Journal 1997; 11: 1333-1340.
67. Wang D, Maule AJ*. Inhibition of host gene expression associated with plant virus replication. Science 1995; 267: 229-231.
68. Wang D, Maule AJ*. A model for seed transmission of a plant virus: genetic and structural analyses of pea embryo invasion by pea seed-borne mosaic virus. Plant Cell 1994; 6: 777-787.
69. Wang D, Maule AJ*. Early embryo invasion as a determinant in pea of the seed transmission of pea seed-borne mosaic virus. Journal of General Virology. 1992; 73: 1615-1620.
70. Wang D, Hayes IM, Maule AJ*. Procedures for the efficient purification of pea seed-borne mosaic virus and its genomic RNA. Journal of Virological Methods. 1992; 36: 223-230.
71. Wang D, Woods D, Swaby AG, Cockbain AJ. Detection of pea seed-borne mosaic virus virion and pinwheel inclusion body proteins in leaf and seed tissues of pea (Pisum sativum L) by immunogold labeling. Agronomie. 1991; 11: 387-394.